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choishingwan / PRSice

A software package for calculating, applying, evaluating and plotting the results of polygenic risk scores
http://prsice.info
GNU General Public License v3.0
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negative statistic observed- how to handle negative effect sizes #310

Open Janina24 opened 2 years ago

Janina24 commented 2 years ago

Hello, just running PRSice and observed that variants with negative beta values have been excluded... For my phenotype especially these variants are interesting...

Here is what is shown in the log file: 4434131 negative statistic observed. Maybe you have forgotten the --beta flag?

Thanks in advance for your help!

choishingwan commented 2 years ago

Maybe you have forgotten the --beta flag?

On Mon, Nov 14, 2022, 8:22 AM janina_epi @.***> wrote:

Hello, just running PRSice and observed that variants with negative beta values have been excluded... For my phenotype especially these variants are interesting...

Here is what is shown in the log file:

4434131 negative statistic observed. Maybe you have forgotten the --beta flag?

Thanks in advance for your help!

— Reply to this email directly, view it on GitHub https://github.com/choishingwan/PRSice/issues/310, or unsubscribe https://github.com/notifications/unsubscribe-auth/AAJTRYTOHQ5TK4HK3BQ5XPDWII4HVANCNFSM6AAAAAAR72FKBU . You are receiving this because you are subscribed to this thread.Message ID: @.***>