cio-abcd / variantinterpretation

Collaborative Interpretation-Pipeline workflow based on nf-core pipeline structure
MIT License
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Support multi-sample VCF files as input #44

Closed sci-kai closed 2 weeks ago

sci-kai commented 2 months ago

This PR addresses Issue #35 for supporting multi-sample VCF files.

The following changes were made:

sci-kai commented 2 weeks ago

I investigated this issue and it seems to be related with vembrane handling missing entries in the FORMAT field. This is discussed in https://github.com/vembrane/vembrane/issues/171 Hence multi-sample VCF files only work if they do not have missing entries. (e.g., if mutect2 calls tumor-normal pairs this is the case, but merged VCF files from different callers may not work). This should be changed within vembrane to handle missing entries.