ciwchris
commented
1 year ago - 258 organ is a structural or anatomic unit in which cells come together to serve a common purpose. Cells in organs are similar to other cells but they also have a special role which serves the orgain.
- 267 rigor mortis is the result of how actin and myosin interact by default. They clasp each other instead of loosen their grip on each other, hence the movement is to let go.
- [[Heart anatomy]], sides of the heard [[atrial]] and [[ventricular]]
- 284 synaptic pruning is thought to sharpen and reinforce the "correct" synapses, while removing the weak and unnecessary ones. We grow mostly by dying. We are hardwired to not be hardwired, and this anatomical plasticity may be the key to the #plasticity of our minds. #glial cells are responsible for this pruning. #microglia are the constant gardeners.
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thought does Alzheimer occur because the neuron isn't being used, it becomes weak, and so it is identified for removal by the microglia?
- 298 #hormones allow cellular communication across the body, instead of only local communication. Pancreas aids in digestion but secrets #insulin to control #gllucose, blood sugar.
- 314 #inflammation, cellular cascade that begins upon injury, repair
- 347 It's as if every organ, and every cell system, has chosen its own kind of Band-Iad for repair and regeneration. ... But the idiosyncrasies of repair in each organ suggest that the individual cellular Band-Aids were cobbled together and remain unique to every organ. To understand injury and repair, then, we have to do it organ by organ and cell by cell. Or perhaps here's a general principle of repair that we art still missing. #research
- In cell biological terms, then, it might be easier to imagine inquiry, or aging, for that matter, more abstractly, as a furious battle between a rate of decay and a rate of repair...
- 351 DNA malfunctions, accelerators and brakes, cancer. Jammed "accelerators" are called oncogenes. "Snapped" brakes are called tumor suppressors. Are not commanders of the cells but commanders of commanders. Two cancer may be genetically different, they behave differently and may require radically different therapies. Even a single breast tumor, then, is actually a collage of mutant cells, an assemblage of nonidentical diseases.
- 360 Warburg effect (note) cancer cell uses the less efficient but fast and cheap mechanism of glucose for producing energy instead of the deep slow burn in mitochondria.
- 363 We have learned the name of the bushes, but not the songs that move between the trees (analogy to bi logical systems, we know the cell we don't know why things are the way they are, their behavior)
- 365 Disease as a violation of the social compacts between cells
- 374 The real "raw material" of the human body is not information (genes), but the way that information is enlivened, decoded, transformed, and integrated - i.e. by cells.
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Book details (JSON)
```json { "title": "The Gene", "authors": [ "Siddhartha Mukherjee" ], "publisher": "Simon and Schuster", "publishedDate": "2016-05-17", "description": "The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).", "image": "http://books.google.com/books/content?id=fOvaCgAAQBAJ&printsec=frontcover&img=1&zoom=1&edge=curl&source=gbs_api", "language": "en", "averageRating": 4, "ratingsCount": 354, "categories": [ "Medical" ], "pageCount": 624, "isbn10": "1476733538", "isbn13": "9781476733531", "googleBooks": { "id": "fOvaCgAAQBAJ", "preview": "http://books.google.com/books?id=fOvaCgAAQBAJ&printsec=frontcover&dq=intitle:The+Song+of+the+Cell,+Siddhartha+Mukherjee&hl=&cd=4&source=gbs_api", "info": "https://play.google.com/store/books/details?id=fOvaCgAAQBAJ&source=gbs_api", "canonical": "https://play.google.com/store/books/details?id=fOvaCgAAQBAJ" } } ```