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cmks / DAS_Tool

DAS Tool
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Cound DAS_Tool re-combine the contig in different methods of bin to one high quality bin #80

Closed neptuneyt closed 2 years ago

neptuneyt commented 2 years ago

Dear DAS_Tool, Thanks for your wonderful work. I was wondering Suppose I get 2 sets of bins by 2 different binning methods, can DAS_Tool re-combine the bins of lower completeness in different methods into bins of higher completeness. For example method_A_bin.1 has 20% completeness of species X and method_B_bin.3 has 60% completeness of species X. So does this software can combine method_A_bin.1 and method_B_bin.3 into a new genome with 80% completeness? Thanks a lot.

cmks commented 2 years ago

No, DAS Tool is not combining bins to increase completeness.

neptuneyt commented 2 years ago

Thanks a lot. So, It is similar with dRep?

cmks commented 2 years ago

Yes, it is similar to dRep but the use cases are different. DAS Tool combines binning predictions from the same assembly, whereas dRep dereplicates bins from different samples/assemblies.

Although the completeness of bins will not increase when running DAS Tool, it is possible that sequence redundancy (aka contamination) of bins can be removed.