magnocellular neurosecretory cell

We seem to have ended up with two classes named identically:

 CL:0011003 ! magnocellular neurosecretory cell
 CL:0011112 ! magnocellular neurosecretory cell

(Oort normally catches this but we turned off this check because label(GO:cell) 
= label(CL:cell)...)

(It's very hard to find the 2nd class in Protege, as it gets confused if you 
have label rendering on)

Text defs:

 CL:0011003 ! magnocellular neurosecretory cell [DEF: "A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that secretes the hormones oxytocin and vasopressin."]

 CL:0011112 ! magnocellular neurosecretory cell [DEF: "Neurons part of the hypothalamic supraoptic and paraventricular nuclei that secrete the hormones, oxytocin and vasopressin into the systemic circulation from the posterior pituitary gland."]

Only the 2nd one has a logical def:

'neuron'[CL:0000540] that capable_of ( 'vasopressin secretion'[GO:0030103] ) & 
capable_of ( 'hormone secretion'[GO:0046879] )

This is probably too lax.

The 1st one is asserted to be a neurosecretory neuron, and part_of:

 - paraventricular nucleus of hypothalamus
 - hypothalamic nucleus

The 2nd assertion is redundant:

          is_a UBERON:0006569 ! diencephalic nucleus
           is_a UBERON:0006568 ! hypothalamic nucleus
            is_a UBERON:0001930 ! paraventricular nucleus of hypothalamus

I think the axioms in both cases are problematic. The location is probably too 
specific. And I think there are two cell types, each with a different 
neurotransmitter (although some can produce both).

See wikipedia:
http://en.wikipedia.org/wiki/Magnocellular_neurosecretory_cell

I can't figure out what is happening with neurolex. There is a redirect page 
that appears to be the superclass of the two NT-specific subtypes:

http://neurolex.org/w/index.php?title=Category:Magnocellular_neurosecretory_cell
&redirect=no

And there is also this page that doesn't have any subclasses:

http://neurolex.org/w/index.php?title=Category:Magnocellular_neurosecretory_cell

In any case, I think the safest thing is to have a hierarchy:

 - magnocellular neurosecretory cell
 -- oxytocin-secreting magnocellular neurosecretory cell
 -- vasopressin-secreting magnocellular neurosecretory cell

The leaves can have equivalence axioms. They should not be disjoint. The 
location should probably be broad, like hypothalamus. Optionally we could have 
a grouping class 'neurosecretory cell of hypothalamus' with a logical 
definition (not sure if there are other types...).

We could also include more specific types for whatever combo of {hypothalamus 
part} x {neurotransmitter} (expert input required. Should be done by TG if at 
all)
Original issue reported on code.google.com by cmung...@gmail.com on 26 May 2014 at 1:22
cmungall / cell-ontology-DO-NOT-USE

magnocellular neurosecretory cell #122
