NTR: mature dendritic cell

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Required to define:

{{{
[Term]
id: GO:0097029
name: mature dendritic cell differentiation
namespace: biological_process
def: "The process in which antigen-activated dendritic cells acquire the 
specialized features of a mature dendritic cell. Mature dendritic cells 
upregulate the surface expression of MHC molecules, chemokine receptors and 
adhesion molecules, and increase the number of dendrites (cytoplasmic 
protrusions) in preparation for migration to lymphoid organs where they present 
antigen to T cells." [GOC:BHF, PMID:15845453, 
http://www.rndsystems.com/mini_review_detail_objectname_MR02_DendriticCellMat.as
px]
comment: Note that immunologists typically use the word 'maturation' to refer 
to dendritic cells undergoing the process that GO describes as 'cell 
differentiation'.
is_a: GO:0097028  ! dendritic cell differentiation
}}}

Original issue reported on code.google.com by cmung...@gmail.com on 24 Jun 2014 at 10:58

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Having read PMID:15845453 closely, I can see that the authors are studying what 
we call 'mature conventional dendritic cell' (CL:0000841).  The authors are 
studying CD11c+ dendritic cells (indicated in Figure S1) which are instances of 
CL:0000990 'conventional dendritic cell' (CD11c = integrin alpha-X).  Upon 
maturation, the authors look for acquisition of CD40, CD80, CD86 and MHC class 
II.  The definition of 'mature conventional dendritic cell' specific reports 
that this cell type bears CD80, CD86 and MHC class II as markers.

Thus I believe the GO term GO:0097029 should be renamed "mature conventional 
dendritic cell differentiation".

I will add a broad synonym "mature dendritic cell" to CL:0000841.

Original comment by addi...@buffalo.edu on 1 Jul 2014 at 5:54