Labels: (1) adult Leydig cell (2) fetal Leydig cell
Synonyms: (1) ALC (2) FLC
Suggested text definition:
(1) The second or "adult" population of Leydig cells (ALCs) that arise between
birth and puberty. ALCs arise in the interstitium of adult testes from unknown
progenitor cells and become the major source of androgens that control
differentiation of the male reproductive tract and spermatogenesis.
(2) The first or "fetal" population of Leydig cells (FLCs) that arise
prenatally. The FLC population increases dramatically during embryonic
development despite the fact that differentiating FLCs are mitotically
inactive, suggesting that expansion of FLC populations results from
differentiation of progenitor cells, rather than cell division of existing
FLCs. The SF1+ cells in gonadal primordia are the primary source of FLCs but
other sources such as neighboring mesonephros, migrating neural crest cells,
and cells from the coelomic epithelium or interstitium are potential
contributors also; at the end of fetal life and during the first 2 postnatal
weeks in rodents. FLCs are gradually replaced by "adult" Leydig cells (ALCs)
but ALCs are not derived from FLCs.
Definition source:
PMID:23568777
(http://www-ncbi-nlm-nih-gov.ezproxy.jax.org/pmc/articles/PMC3688755/),
PMID:11420130, PMID:15037365 and MGI:Anna (see also
http://sourceforge.net/p/obo/mammalian-phenotype-requests/1977/)
Original issue reported on code.google.com by cynthia....@jax.org on 4 Mar 2015 at 7:13
Original issue reported on code.google.com by
cynthia....@jax.orgon 4 Mar 2015 at 7:13