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cmungall / cell-ontology-DO-NOT-USE

Initial attempt to move repo from gcode. USE OBOPHENOTYPE
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progenitor cell of endocrine pancreas is not a stem cell #80

Open GoogleCodeExporter opened 9 years ago

GoogleCodeExporter commented 9 years ago 
The current definition of a 'progenitor cell of endocrine pancreas' is a 
multi-fate stem cell is wrong. Generally stem cells give rise to progenitor 
cells so the is_a relation seems wrong. For this specific case, the cells 
generating islet cells and expressing neurogenin-3 and Isl1 are transitory and 
don't represent a population of cells that 'proliferate throughout life to 
provide progenitor cells'. See for example section 4 on page 679 in Rieck, 
Bankaitis, and Wright Lineage determinants in early endocrine development. 
Seminars in Cell & Developmental Biology 23 (2012) 673-684.

Original issue reported on code.google.com by stoec...@upenn.edu on 1 Jul 2013 at 7:03

GoogleCodeExporter commented 9 years ago

Original comment by vasil...@ohsu.edu on 2 Dec 2014 at 7:13