acidemia vs acidosis confusion

[cmungall]

Originally reported on Google Code with ID 7

Elk says

Acidosis = acidosis = acidemia

HP:

Acidosis is a condition in which there is excessive acid in the body fluids.

has_part some 
    ('increased concentration'
     and ('inheres in' some blood)
     and (towards some acid))

"Acidemia" is an exact synonym

MP:

a pathological state characterized by an increase in the hydrogen ion concentration
in tissues and blood caused by an decrease in the concentration of alkaline compounds,
or by a increase in the concentration of acidic compounds or carbon dioxide to the
body fluids

has_part some 
    ('increased concentration'
     and (towards some acid)
     and ('inheres in' some blood)
     and ('inheres in part of' some artery))

acidemia is a distinct class, def: "increased concentration of H-ion in the blood or
a fall below normal in pH in the arterial blood"

Analysis:

(acidosis) The HP text def is straightforward, but the logical definition is too specific
for the text (blood -> bodily fluid)

(acidosis) The MP test def is more verbal and brings in aetiology. The logical definition
is probably too specific for the text ("arterial blood"). Not clear what the intended
location here?

Suggestion:

(acidosis) Standardize on a simple def, e.g. the HP one. Include aetiology and additional
text after period. Make the logical def use bodily fluid in both.

(acidemia) keep MP as is; weaken HP exact syn to related.

Reported by cmungall on 2014-02-03 02:32:11

[cmungall]

Slight correction to the above - the 3-ary equivalence is due to lexical matching, not
reasoning. Doesn't affect recommended course of action.

Reported by cmungall on 2014-02-03 02:39:15

[cmungall]

Additional notes: in MP, acidemia is under abnormal blood pH regulation, whereas is
under the more general non-blood-specific acidosis, supporting the above

Reported by cmungall on 2014-02-03 02:43:34

[cmungall]

This issue was closed by revision r433.

Reported by cmungall on 2014-02-03 02:45:17

• Status changed: Fixed

[cmungall]

Implemented the above for equivalence axioms with commit 433, still to resolve syns/text
defs

Reported by cmungall on 2014-02-03 02:46:27

• Status changed: Started

[cmungall]

From Peter:

Clinically these terms are used nearly interchangeably, since you get acidemia if you
have acidosis and only almost always measures acidosis via the blood. There is more
of a mechanistic touch to the acidosis terms ("metabolic acidosis"), and this is an
inference which is in principle so certain clinically that it is regarded as a phenotypic
feature. The wikipedia entry is correct

The term acidemia describes the state of low blood pH, while acidosis is used to describe
the processes leading to these states. Nevertheless, the terms are sometimes used interchangeably.

http://en.wikipedia.org/wiki/Acidosis

This might be a good suggestion of how to define the terms, one based on the actual
observation, the other based on the inferred abnormal process.

Reported by cmungall on 2014-02-03 16:18:56

[cmungall]

See also:
https://en.wikipedia.org/wiki/Metabolic_acidosis

Reported by cmungall on 2014-02-03 16:27:20