cole-trapnell-lab / monocle3

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Multiple non-continuous batches with align_cds? #712

Open professor-sagittarius opened 5 months ago

professor-sagittarius commented 5 months ago

Is it possible to align across multiple discrete batches (alignment_groups) in align_cds? I could be mistaken, but the function appears to modify the PCA from preprocess_cds, overwriting the previous Aligned reduction with no option to modify it instead, thus precluding an iterative approach. Any advice would be greatly appreciated!