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colomemaria / epiAneufinder

R package to detect breakpoints and assign somies to scATAC-seq data
GNU General Public License v3.0
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Question about euploid samples #28

Open emanuelavilla opened 2 months ago

emanuelavilla commented 2 months ago

Hello! Thanks for this interesting tool!

I have a question for you: I could not well understand from the paper if the tool could work for diploid cells (for example I am working on scATAC-Seq data from pre-leukemic murine cells).

Thanks

thek71 commented 2 months ago

Hi,

in the paper we have a examples of different diploid samples (brain, bone marrow and PBMCs) that epiAneufinder should not have identified CNVs. What we did find and report in the paper is that there where actually no CNVs found, just some random noise. Based on the above, we conclude that epiAneufinder manages to identify diploid samples as such.

Best, Katia