luyi0629
commented
3 years ago Here, check this method https://www.nature.com/articles/s41588-021-00787-1
Best, Lu Yi
From: joellepasman @.> Sent: Thursday, August 12, 2021 2:35 PM To: comorment/containers @.> Cc: Subscribed @.***> Subject: [comorment/containers] Tool for distinguishing loci (#10)
Jacob and me were wondering if some tool exists that does the opposite of genetic correlations, namely identify loci that are specific for a trait. Say you want to compare summary statistics for bipolar disorder and depressive disorder, and you want to identify loci that are not shared between the two, is there a tool to identify those? You can do something like that with genomic SEM or by eyeballing circular manhattan plots, but I could not think of a tool that specifically identifies non-shared variants.
If such a tool exists we would love to have it in the container toolbox.
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joellepasman
github-actions[bot]
Jacob and me were wondering if some tool exists that does the opposite of genetic correlations, namely identify loci that are specific for a trait. Say you want to compare summary statistics for bipolar disorder and depressive disorder, and you want to identify loci that are not shared between the two, is there a tool to identify those? You can do something like that with genomic SEM or by eyeballing circular manhattan plots, but I could not think of a tool that specifically identifies non-shared variants.
If such a tool exists we would love to have it in the container toolbox.