Open hsun3163 opened 3 years ago
Hi there,
Thanks for reaching out! It looks like we have an issue using --low-mem with LMM association analysis. The --low-mem option only affects how genotypes are loaded, so it should not be an issue for fitting null models, as you noticed.
I'll make a note to patch this. In the meantime, your best bet is to avoid using --low-mem for LMM association analysis.
If you find that memory usage is prohibitive (i.e., you have many variants and many samples), then you can manually specify smaller chunks using the --region and --bed-region flags.
Best, Corbin
Dear Apex author,
I have encountered a issue in using LMM for Apex Cis/Trans
For the cis analysis, with the following commands:
This error has occurred:
Similarly, for the trans analysis, with the following command:
The same error has occurred:
The GRM matrix used are shown as followed:
The same GRM matrix can be successfully used in the apex lmm with the following output.