cov-lineages / constellations

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Documentation for new components of constellation definitions (incompatible, intermediate) #32

Closed aretchless closed 2 years ago

aretchless commented 2 years ago

Hello. We're trying to figure out the recent changes to AY.4.2 calls between versions, and it seems to come down to the 'incompatible lineage' component of the constellation definitions. (https://github.com/cov-lineages/constellations/compare/v0.0.17...v0.0.20)

Could you please provide a description of what this part of the constellation file means? Also, what are the "intermediate" mutations that are listed? Below are the relevant sections from AY.4:

    "variant": {
    "Pango_lineages": [
        "AY.4"
    ],
    "mrca_lineage": "AY.4",
        "lineage_name": "AY.4",
        "parent_lineage": "B.1.617.2",
        "incompatible_lineage_calls": [
            "AY.4.2"
        ],
    "representative_genome": ""
    },
    ],
    "intermediate": [
        "nuc:G210T:0.976009",
        "nuc:T17040C:0.976009",
        "spike:T95I:0.976009",
        "spike:G142D:0.976009"
    ],

Thanks.

rmcolq commented 2 years ago

I've added to the README in the above commit which will be merged in shortly. Hope that description helps

aretchless commented 2 years ago

Thanks a lot Rachel!