EG.5.1.3+Orf1a:T2274I+S:L455F,S704L(70 seqs, 15 countries)

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From https://github.com/sars-cov-2-variants/lineage-proposals/issues/664 EG.5.1.3+C7086T(Orf1a:T2274I)+G22927T,C23673T(S:L455F,S704L)

GISAID query: G22927T,C23673T,C1889T No. of seqs: 10(Denmark 1 Spain 4 USA 2(1 from Italy, 1 from Spain), Canada 2 France 1) 12 on GISAID however there are 2 pairs of GBW-H10/H20 duplicate, so actual number is 10.

First: EPI_ISL_18123382, France, 2023-7-8 Latest: EPI_ISL_18151035, Canada, 2023-8-21

usher

[FedeGueli]

13 now.+1 Denmark and France

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23 seqs now, Belgium, Brazil,

[FedeGueli]

@corneliusroemer this is another one growing fast, as said in other places my view we should designate at least these ones clearly growing fast. doubling 7days the half of currently dominant lineages.

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34 now, new country of Finland

It triples in a week!

2 weeks ago it has 2 seqs, 1 week ago it has 10 seqs, now it has 34.

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There seems to exist a UK-CLIMB seq of this now. So 35.

[FedeGueli]

There seems to exist a UK-CLIMB seq of this now. So 35.

Yeah consider that S:S704L managed to reach 2% globally overcoming more discussed mutations as 356/403/613 and also catching S:554 . And it seems working very well with FLip in GK.1.1

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There seems to exist a UK-CLIMB seq of this now. So 35.

Yeah consider that S:S704L managed to reach 2% globally overcoming more discussed mutations as 356/403/613 and also catching S:554 . And it seems working very well with FLip in GK.1.1

Yeah this branch seems to be the fastest among Flips. Doubling in 3~4 days.

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+1 Germany

[FedeGueli]

42 Scotland Wales France with G22927T,C23673T,C1889T 40 with C7086T,G22927T,C23673T,C1889T

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42 Scotland Wales France with G22927T,C23673T,C1889T 40 with C7086T,G22927T,C23673T,C1889T

Those without C7086T seems to be masking?

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46,Ireland.

[FedeGueli]

already 49

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51, Australia

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53,Canary Islands (3 GBW H10/20 pairs now)

[FedeGueli]

60 now.

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+1 Austria

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@FedeGueli @corneliusroemer This one seems one scale faster than the fastest lineages. (BA.2.86 and HK.3)

[FedeGueli]

@FedeGueli @corneliusroemer This one seems one scale faster than the fastest lineages. (BA.2.86 and HK.3)

Agree very much in my sheets it is the fastest on earth as today (with all the limitations implied in what we can track) cc @corneliusroemer please check this one

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70, Romania

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@FedeGueli @corneliusroemer This one seems one scale faster than the fastest lineages. (BA.2.86 and HK.3)

Agree very much in my sheets it is the fastest on earth as today (with all the limitations implied in what we can track) cc @corneliusroemer please check this one

This is basically the same Flip+704+Orf9b:5T as XCH, plus Q52H and some EG.5.1-specific Orf1ab mutations

[FedeGueli]

It seems to have acquired S:T307I too in a half dozen of Uk CLimb sequences. Ushering them: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3bc0f_6ca290.json?label=id:node_6988676

Already 14! just 4 of them On Gisaid (from Denmark 3, Germany 1 ):

[FedeGueli]

Ping @corneliusroemer i suggest to prioritize this one.

[FedeGueli]

One of them England/CLIMB-CM7YEDCI/2023|2023-09-06 has S:T345I that disrupts N343 Glycan , this N Glycan is a key for gating: the transitioning from RBD Down to Up to Open conformation : https://www.nature.com/articles/s41557-021-00758-3

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It seems to have acquired S:T307I too in a half dozen of Uk CLimb sequences. Ushering them: https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/subtreeAuspice1_genome_3bc0f_6ca290.json?label=id:node_6988676

Already 14! just 4 of them On Gisaid (from Denmark 3, Germany 1 ):

There is another EG.5.1+Flip+307I variant https://github.com/sars-cov-2-variants/lineage-proposals/issues/631

[FedeGueli]

Designated JG.3