It would certainly run, but you would have to be careful with the results, you wouldn't want to filter anything because of a poor-quality unmatched normal sample. I guess it might help clean up regions of poor quality alignment/sequencing. I should really finish adding the tumor-only mode I've been intending to implement.
If you've got a specific use-case or project in mind, feel free to email me and we can discuss it further.
It would certainly run, but you would have to be careful with the results, you wouldn't want to filter anything because of a poor-quality unmatched normal sample. I guess it might help clean up regions of poor quality alignment/sequencing. I should really finish adding the tumor-only mode I've been intending to implement.
If you've got a specific use-case or project in mind, feel free to email me and we can discuss it further.