Take a look into Nuitka

[craftamap]

MacOS users often have problems with the python ecosystem, so why don't we offer simple binaries (maybe even over brew?)

https://github.com/Nuitka/Nuitka could be the solution.

[craftamap]

Building native (linux) binaries seems to work, if we supply another script calling pluploader manually:

import pluploader.main

pluploader.main.main()

Now I need to get access to a Mac and try Nuitka there.

[craftamap]

A brew recipe without nuitka seems to be easier, I guess. Let's go this route and see how far we can go.