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crisprVerse / crisprScore

On-Target and Off-Target Scoring Algorithms for CRISPR gRNAs
MIT License
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CRISPRoff #3

Open Jfortin1 opened 2 years ago

Jfortin1 commented 2 years ago

From https://github.com/Jfortin1/crisprScore/issues/5:

Hi, I have been using your new CRISPR Design tools recently and found it to be very helpful in CRISPR gRNA design. While I was searching for the best performing off-target prediction algorithms, I found those two more recent method: Microsoft ML-based Elevation score (sister algorithm of the Azimuth on-target prediction), and the gRNA binding free energy based ML algorithm-CRISPRoff. Both showed superior performance than the MIT score and CDF scores, especially the CRIPSRoff Score. I wonder if you could integrate those two methods in your off-target prediction methods collection. Below are the links: https://github.com/microsoft/Elevation https://github.com/RTH-tools/crisproff Thank you for considering. Best, Zhibo