d3b-center / OpenPedCan-analysis

The analysis repository for the Open Pediatric Cancer Project
https://d3b-center.github.io/OpenPedCan-analysis/
Other
15 stars 13 forks source link

Proposed Analysis: Medulloblastoma SHH subtyping #564

Closed jharenza closed 2 weeks ago

jharenza commented 3 months ago

What are the scientific goals of the analysis?

Further subtype MB-SHH into one of the 4 SHH classes: SHH-1 (-β), SHH-2 (- γ), SHH-3 (-α), or SHH-4 (-δ)

What methods do you plan to use to accomplish the scientific goals?

What input data are required for this analysis?

histologies.tsv, CNV, expression files, potentially MAF

How long do you expect is needed to complete the analysis? Will it be a multi-step analysis?

Who will complete the analysis (please add a GitHub handle here if relevant)?

@rjcorb and @jharenza

What relevant scientific literature relates to this analysis?

From this review

Four main subtypes have been defined – SHH-α, -β, -γ, and -δ – and these will be formally recognized in the forthcoming edition of the WHO Classification of Central Nervous System Tumors and redesignated SHH-1 (-β), SHH-2 (- γ), SHH-3 (-α), and SHH-4 (-δ)