d3b-center / pbta-splicing

Splicing analysis across the PBTA
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Proposed Analysis: SRSF1 vs CLK1 Exon 4 PSI correlations #153

Closed naqvia closed 12 months ago

naqvia commented 1 year ago

What are the scientific goals of the analysis?

We want to assess if SRSF1 expression levels are correlated with Exon 4 inclusion. Previous studied have found high density of binding sites within Exon 4, suggesting that SRSF1 controls exon 4 inclusion levels.

What methods do you plan to use to accomplish the scientific goals?

Pearson correlation

What input data are required for this analysis?

SRSF1 expression and CLK1 Exon 4 PSI

How long do you expect is needed to complete the analysis? Will it be a multi-step analysis?

1-2 days

Who will complete the analysis (please add a GitHub handle here if relevant)?

@naqvia

What relevant scientific literature relates to this analysis?

https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(18)30592-4

jharenza commented 12 months ago

completed with #150