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danro9685 / ASCETIC

ASCETIC (Agony-baSed Cancer EvoluTion InferenCe) is a novel framework for the inference of a set of statistically significant temporal patterns involving alternations in driver genes from cancer genomics data. Manuscript published at: https://www.nature.com/articles/s41467-023-41670-3
https://danro9685.github.io/ASCETIC/
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How CCF be calculated for gene level #11

Closed wt12318 closed 4 months ago

wt12318 commented 4 months ago

Hi, Thanks for the tool. In the paper, each figure was shown as gene level evolutional signature. And the ccf was usually calculated in mutation level, how could it trans into gene level and use this tool (one gene might have multiple mutations and thus have many CCF values)? Thanks

danro9685 commented 4 months ago

Dear @wt12318, Thank you for the interest in our framework. In the paper if I get had multiple mutations, we considered for each patient the one at higher CCF (occurring earlier). All the best, Daniele Ramazzotti