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data2health / ehr2HPO.prj

Conversion of EHR data (such as LOINC) to HPO codes
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Implement synergy algorithm (test case) #13

Closed pnrobinson closed 4 years ago

pnrobinson commented 5 years ago

Implement the algorithm described here and test it using artificial or genomic data as preparation for the CTSA analysis

Watkinson J, Wang X, Zheng T, Anastassiou D. Identification of gene interactions associated with disease from gene expression data using synergy networks. BMC Syst Biol. 2008;2:10. Anastassiou D. Computational analysis of the synergy among multiple interacting genes. Mol Syst Biol. 2007;3:83.

pnrobinson commented 5 years ago

Initial summary of algorithm finished,

kingmanzhang commented 5 years ago

We have implemented the algorithm with python using the Numpy library. Numpy is a standard library for numeric computation. There is a Java counterpart, ND4J, if we want to implement this in Java.