Designing Interface Residues

dauparas / ProteinMPNN

Code for the ProteinMPNN paper

MIT License

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Designing Interface Residues #62

Open linamp opened 1 year ago

linamp commented 1 year ago

I am trying to design an interface, but the amino acids I am getting are almost completely polar, which is weird for an interface. Am I missing something? Is there something one should consider when designing interfaces? I am quite sure that the distance I am using between the two chains is adequate for an interface.

jadolfbr commented 8 months ago

What I'm thinking is happening is that even if you are not designing B, B should be given as the chains, otherwise it seems to assume that chain B is not there... Going to open an issue and see if this is really the case or something else weird.