search

debbiemarkslab / plmc

Inference of couplings in proteins and RNAs from sequence variation
MIT License
104 stars 37 forks source link

How to get a2m MSA? #20

Open jackhu3301 opened 1 year ago

jackhu3301 commented 1 year ago

I am really new to MSA, would you mind telling me how to get the a2m file that this package required? Thank you very much.

mmagnus commented 1 year ago

To create an .a2m file, you can perform a multiple sequence alignment of your protein or nucleotide sequences using a software such as Clustal Omega, MAFFT, or MUSCLE, JALVIEW. These software packages can generate .a2m files directly or can convert the output into the A2M format.