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dekkerlab / crane-nature-2015

code associated with crane-nature-2015, 10.1038/nature14450
Apache License 2.0
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different insulation scores between *.insulation file and *.insulation.boundaries file #6

Open YusenYe opened 6 years ago

YusenYe commented 6 years ago

This is test data's output in your packages.

The output of N2-DpnII10kbchrX.is500001.ids200001.insulation: bin6000201|ce10|chrX:2010001-2020001 2010001 2020001 2015001 201 202 201.5 -0.237082756600542 -0.00117094427035152 -1

The output of N2-DpnII10kbchrX.is500001.ids200001.insulation.boundaries: boundary.3|ce10|chrX:2010001-2020001 2010001 2020001 201 202 201.5 bin6000201|ce10|chrX:2010001-2020001 0.484256934770599

I want to know the difference of insulatioscore between the two files.

Thank you very much! Yusen

kellyliyichen commented 6 years ago

Hi,

I have the same question. I guess that the insulationScore in the .insulation.boundaries file may be the insulation strength (not sure), which means the larger the number, the more possible that a bin is a TAD boundary. However, the insulationScore of a bin in the .insulation file is calculated by the mean contacts crossing the current bin, so the boundary is the local minimum of insulationScore.

kkkaiqiang commented 4 years ago

This is test data's output in your packages.

The output of N2-DpnII10kbchrX.is500001.ids200001.insulation: bin6000201|ce10|chrX:2010001-2020001 2010001 2020001 2015001 201 202 201.5 -0.237082756600542 -0.00117094427035152 -1

The output of N2-DpnII10kbchrX.is500001.ids200001.insulation.boundaries: boundary.3|ce10|chrX:2010001-2020001 2010001 2020001 201 202 201.5 bin6000201|ce10|chrX:2010001-2020001 0.484256934770599

I want to know the difference of insulatioscore between the two files.

Thank you very much! Yusen

I have the same question. So have you figured it out?