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diazlab / CONICS

CONICS: COpy-Number analysis In single-Cell RNA-Sequencing
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Can or should we do batch-correction before parsing the log2cpm to CONICSmat? #20

Open biobug16 opened 4 years ago

biobug16 commented 4 years ago

Hi @diazlab and @soerenmueller I want to do the batch-correction for my samples before predicting CNVs using CONICSmat. Do you recommend any method for batch-correction as my histogram for the Zscore and for the posterior probabilities, do not represent few of my samples properly. Will batch-correction help in this regard. Is there any step within CONICSmat which takes care of this issue and may be I am missing it? Any suggestion will be appropriated. Thanks