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diazlab / CONICS

CONICS: COpy-Number analysis In single-Cell RNA-Sequencing
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detection of CNV in germlines #37

Open lmanchon opened 2 years ago

lmanchon commented 2 years ago

--Hi,

2 questions: is CONICS able to detect CNV in germlines single cells ? and is there a way to compute mosaicism rate ?

thank you --

diazlab commented 2 years ago

Yes, but you will need to define a control population without CNVs.

You will get a CNV call for each cell which you could use to estimate the percentage of cells with the alteration.