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ding-lab / hotspot3d

3D hotspot mutation proximity analysis tool
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PyMOL question : Is pymol show the changed structure or original structure if mutations in the clusters #24

Closed wangweifeng2018 closed 5 years ago

wangweifeng2018 commented 5 years ago

Good morning,

   I have a question about pymol. I understand the how hotspot3d predict the clusters. But when I read a paper “Pathogenic Germline Variants in 10,389 Adult Cancers”，Figure 7B in the paper show the protein structures gene RET and MET. All the mutations are very close to each other. As far as I know those mutations are not clustered in the original proteins. I want to know if the pymol can show the changed structure when mutation influence the protein 3d structure.

Thanks.

Best, Weifeng

wangweifeng2018 commented 5 years ago

Sorry about the terrible edition. I have a question about pymol. I understand the how hotspot3d predict the clusters. But when I read a paper “Pathogenic Germline Variants in 10,389 Adult Cancers”， Figure 7B in the paper show the protein structures gene RET and MET. All the mutations are very close to each other. As far as I know those mutations are not clustered in the original proteins. I want to know if the pymol can show the changed structure when mutation influence the protein 3d structure.

Weifeng