Closed Caleb-Carr closed 4 weeks ago
@jbloom This notebook compares the functional scores calculated for barcoded variants with single amino-acid mutations to the functional effects of mutations inferred from the global epistasis model. Overall, seems like scores are highly correlated.
Yes, this looks good. I would suggest adding a few additional things:
times_seen
parameter you report as a tooltip is a bit confusing as it is the times_seen
only for the global epistasis functional effects (as I understand it). Can you report a times_seen
for both all barcoded variants and just single amino-acid mutant variants.Then after that this should basically be good and we can convert to a supplemental figure.
Sounds good! Just one follow up question related to point one above. Does this mean add a tooltip that says for X mutation, it is seen Y times across all barcoded variants and Z times in single mutant barcoded variants?
Yes
@jbloom Updated notebook:
times_seen
for both single mutant variants and all variants as a tooltipsSounds good. For the paper I think we should probably add in the supplement the plot with the >= 2 times seen in single mutants, since that is the comparable threshold to what we use for times_seen for global epistasis fit models.
Create a correlation plot for single mutant variant scores and the deconvolved single mutant functional effects inferred from the global epistasis model.