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Should we use different icXX for sera #15

Closed Bernadetadad closed 1 year ago

Bernadetadad commented 1 year ago

Many sera selections go from low neutralization (0.8-0.4) to very potent neutralization (0.009) so I wonder if actually using lower icXX (70?) would be better.

jbloom commented 1 year ago

It's up to you. In general, this should really only matter much for sera that do not get close to 100% neutralization where (as noted in prior issue) a IC90 will be problamtic. I would suggest picking a IC90, IC80, or IC50 just because those are the standard things you see in literature. If sera all neutralize completely, I still think IC90 best. But if they don't, then maybe one of the others.

jbloom commented 1 year ago

In the newest pipeline version, the ICXX values are not shown at all by default in the displayed docs as they seem to add little information beyond the mutation or raw affinity values and we aren't sure that the correlation with true values has a slope of one.

So closing this issue for now.