N+1 calling as way to enhance small dataset accuracy

dnanexus-rnd / GLnexus

Scalable gVCF merging and joint variant calling for population sequencing projects

Apache License 2.0

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N+1 calling as way to enhance small dataset accuracy #280

Open JosephLalli opened 1 year ago

JosephLalli commented 1 year ago

Hi there,

I was wondering - is this a valid way to improve variant calling? In theory, can you take a large cohort dataset such as 1000G or even UK Biobank and merge it with your own a private dataset called on a functionally equivalent pipeline?

Thanks!

Originally posted by @JosephLalli in https://github.com/dnanexus-rnd/GLnexus/issues/233#issuecomment-1360640383