dohlee / metheor

:comet: Ultrafast DNA methylation heterogeneity calculation from bisulfite alignments (Lee et al., PLOS Computational Biology. 2023)
GNU General Public License v3.0
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Obtaining counts of CpG quartets #20

Open stephenshank opened 12 months ago

stephenshank commented 12 months ago

First, thank you for your work on this package, it is very impressive and useful!

I am curious as to whether the CpG quartet counts can be obtained as a byproduct of the epipolymorphism calculation. After reading the documentation it seems like this is a feature request. I ask because we are interested in calculating temporal changes in epiallele frequencies for polymorphic loci in AML.

I would envision another 16 columns in the output table, corresponding to each possible quartet.