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dohlee / metheor

:comet: Ultrafast DNA methylation heterogeneity calculation from bisulfite alignments (Lee et al., PLOS Computational Biology. 2023)
GNU General Public License v3.0
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Support BED input? #21

Open PanZiwei opened 9 months ago

PanZiwei commented 9 months ago

Hi, Thanks for the amazing tool. I already have per-site methylation calling results from long-read sequencing in BED format with chromosome, start position, end position, and methylation frequency for each CpG site.

Is it possible to use the BED file as metheor input for methylation heterogeneity measures analysis? Any hints for the implementation? Thanks.

Jampion-Zhang commented 3 months ago

The BED file lacks information about reads, thus I believe it cannot be utilized as input for calculating heterogeneity.