Hierarchical nature of bacterial categories not considered in STAMP?

donovan-h-parks / STAMP

Statistical Analysis of Metagenomic Profiles

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Hierarchical nature of bacterial categories not considered in STAMP? #30

Open Jigyasa3 opened 5 years ago

Jigyasa3 commented 5 years ago

Hey @dparks1134

I wanted to ask if STAMP considers the hierarchical structure of bacterial taxa in statistical testing? For example, If I am comparing the difference in proportion of two bacterial species (from the same bacterial genera), in two groups (control vs disease). Would STAMP consider that the reason both the species are significantly different in control vs disease group is that they are closely related to each other?

donovan-h-parks commented 5 years ago

None of the tests in STAMP consider the hierarchical relationship between taxa.