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dviraran / xCell

Cell types enrichment analysis
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xCell for proteomics? #71

Open fabiostrindade opened 1 year ago

fabiostrindade commented 1 year ago

Hi, I was wondering whether it is possible to use xCell to make cell-type enrichment analysis based on proteomics data. And if so, should one use raw quantification (label-free, for instance) data? Tks, Fábio Trindade

dviraran commented 1 year ago

Hi,

The current version of xCell is not customizable. We are working hard to finalize a new version that will be customizable. xCell identifies genes/proteins that are differentially expressed in the cell type, so makes sense to train it with normalized data (but again, that will be possible only in the xCell 2.0).

Best, Dvir

fabiostrindade commented 1 year ago

Hi Dvir,

Thanks for your feeback. I am giving it a try with normalized data. Let's see how it goes.

Best, Fábio