Enhancement Request: Integration of Mayne et al. (2017) 62 CpG Clock

[dw1227]

• Incorporate the 62 CpG clock developed by [Mayne et al. (2017)] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040051/).

• To ensure complete evaluation, update all relevant plots, including parity plots and eGA acceleration plots, to include this clock.

[dw1227]

After conducting some exploratory analysis, I've determined that the Mayne clock is not ideally suited for use with 850k probes. This is primarily due to the absence of one of the seven missing probes, specifically cg13678049, which has a significant coefficient of over 8 in the Mayne clock. I think that the absence of this probe on the 850k array results in an RMSE of 5 weeks on our test data. Given this limitation, I will focus on generating plots using only the 450k data collected from public databases. This approach will help us better understand the characteristics and performance of the Mayne clock within the available data.