dyxmvp / Spatial_ATAC-seq

20 stars 12 forks source link

Reproducibility of human tonsil data analysis #4

Open Irisapo opened 2 years ago

Irisapo commented 2 years ago

Hi,

Can you guys help me in reproducing the clustering and gene score results on the human tonsil data? There might be something I did wrong, as I am only able to get 2 clusters, and half of the genes predicted non-zero scores with the parameter settings you guys have in the script/paper. Here is what I did:

I filtered out 12 spots as you guys did, 
I then used the 2488 remaining spots to do dimensionality reduction (addIterativeLSI) and clustering (addClusters). 
The gene scores were then calculated using addImputeWeights. 
All the parameters I used are the same from the manuscript/your script. 

As I am noticing that the script you guys provided here are specific for mouse datasets. I wondering whether I have missed anything.

Thank you for your help in advance! Shiyi