ebi-chebi / ChEBI

Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on ‘small’ chemical compounds.
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mucopolysaccharide and hyaluronic acid #1288

Open muthuvenkat opened 16 years ago

muthuvenkat commented 16 years ago

mucopolysaccharide and hyaluronic acid are undefined in CHEBI

http://www.thefreedictionary.com/hyaluronic+acid

hyaluronic acid - a viscous mucopolysaccharide found in the connective tissue space and the synovial fluid of movable joints and the humors of the eye; a cementing and protective substance

This suggests an is_a relation (not in CHEBI)

I trust wikipedia a little more than free dictionary:

http://en.wikipedia.org/wiki/Mucopolysaccharide redirects to Glycosaminoglycan

which suggests these might be synonyms?

CHEBI does say hyaluronic acid is_a glycosaminoglycan - so merging Mucopolysaccharide and Glycosaminoglycan would seem to result in all 3 sources agreeing.

This suggests another synset: http://en.wikipedia.org/wiki/Hyaluronan

disclaimer: I know nothing of this area, got here via a tangent, just trying to get consistency between the different resources..

Reported by: cmungall

muthuvenkat commented 16 years ago

no, mucopolysaccharide and glycosaminoglycan are not the same.

mucopolysaccharide (CHEBI:37395) Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid.

glycosaminoglycan (CHEBI:18085) Any polysaccharide containing a substantial proportion of aminomonosaccharide residues. (i.e. does not necessarily contain uronic acid reidue)

Accoridng to Oxford Dictionary of BMB, mucopolysaccharides include hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan sulfate and heparin.

Now hyaluronic acid (CHEBI:16336) is a mucopolysaccharide (CHEBI:37395) mucopolysaccharide (CHEBI:37395) is a glycosaminoglycan (CHEBI:18085)

I have removed the relation: hyaluronic acid (CHEBI:16336) is a glycosaminoglycan (CHEBI:18085)

That change only will be visible in next (October) ChEBI release

Kirill

Original comment by: kiri11