muthuvenkat
commented
15 years ago Unfortunately, I couldn’t find a whole lot of primary information on this drug. Sorry about that! Hope this is enough to at least lead you in the right direction. I ran across it while curating the yeast drug-resistance phenotypes in this publication:
Fleming JA, Lightcap ES, Sadis S, Thoroddsen V, Bulawa CE, Blackman RK. Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1461-6. PMID: 11830665
You will probably also want to create an entry for the compound that PS-519 is derived from, lactacystin. There’s a mimimal wikipedia entry for it http://en.wikipedia.org/wiki/Lactacystin
Original comment by: diannafisk
Definition: A beta-lactone proteasome inhibitor derived from lactacystin.
References: Elliott PJ, Zollner TM, Boehncke WH. Proteasome inhibition: a new anti-inflammatory strategy. J Mol Med. 2003 Apr;81(4):235-45 PMID: 12700891
François Soucy, Louis Grenier, Mark L. Behnke, Antonia T. Destree, Teresa A. McCormack, Julian Adams,* and Louis Plamondon A Novel and Efficient Synthesis of a Highly Active Analogue of clasto-Lactacystin β-Lactone J. Am. Chem. Soc., 1999, 121 (43), pp 9967–9976 http://pubs.acs.org/doi/full/10.1021/ja991175f
Reported by: diannafisk