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ebi-chebi / ChEBI

Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on ‘small’ chemical compounds.
https://www.ebi.ac.uk/chebi
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Rebeccamycin biosynthesis compounds #1683

Closed muthuvenkat closed 8 years ago

muthuvenkat commented 14 years ago

Hi,

I need a number of compounds for the rebeccamycin biosynthesis pathway. See: http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/misc/rebecca.html

2-imino-3-(7-chloroindol-3-yl)propanoate dichlorochromopyrrolate dichloroarcyriaflavin A (= rebeccamycin aglycone) 4′-demethylrebeccamycin rebeccamycin

EC 1.4.3.23 7-chloro-L-tryptophan + O2 = 2-imino-3-(7-chloroindol-3-yl)propanoate + H2O2

EC 1.13.12.17 dichlorochromopyrrolate + 3 O2 + 3 NADH + 3 H+ = dichloroarcyriaflavin A + 2 CO2 + 4 H2O + 3 NAD+

EC 2.1.1.164 4′-demethylrebeccamycin + S-adenosyl-L-methionine = rebeccamycin + S-adenosyl-L-homocysteine

/Kristian

Reported by: axelsen

muthuvenkat commented 14 years ago

Hi Kristian. I have curated the following compounds as requested.

2-imino-3-(7-chloroindol-3-yl)propanoate (CHEBI:59194)

dichlorochromopyrrolate (CHEBI:59198, parent acid CHEBI:59196)

dichloroarcyriaflavin A (CHEBI:330772)

4′-demethylrebeccamycin (CHEBI:595389)

rebeccamycin (CHEBI:135511)

Please note the structures of the last two compounds shown in the IUBMB link are not correct. The glucose rings have OH rather than CH2OH groups at the 5-position.

Steve

Original comment by: stevet7

muthuvenkat commented 14 years ago

Original comment by: G-Owen