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ebi-chebi / ChEBI

Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on ‘small’ chemical compounds.
https://www.ebi.ac.uk/chebi
Creative Commons Attribution 4.0 International
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Non-coding RNA #3125

Open muthuvenkat opened 8 years ago

muthuvenkat commented 8 years ago

long non-coding RNA: I used definition from wikipedia: Long non-coding RNAs (long ncRNAs, lncRNA) are non-protein coding transcripts longer than 200 nucleotides. Alternative term: lncRNA Parent: ribonucleic acid I added the following from wikipedia as an editor note: This somewhat arbitrary limit distinguishes long ncRNAs from small regulatory RNAs such as microRNAs (miRNAs), short interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs), and other short RNAs

small interfering RNA: I adapted the definition from wikipedia: small interfering RNA (siRNA) is a class of double-stranded RNA molecules, 20-25 base pairs in length. siRNA plays many roles, but it is most notable in the RNA interference (RNAi) pathway, where it interferes with thes expression of specific genes with complementary nucleotide sequences. Parent: ribonucleic acid Alternative term: siRNA

microRNA : Suggest adapting from SO_0000276

RNA(circular) CHEBI:876 Make child of ribonucleic acid

Reported by: alanr

bmeldal commented 8 years ago

Hi,

If these are originally @NancyCampbell 's requests I'll be responding to this ticket from now on as Nancy is going on leave for a year :)

@NancyCampbell, could you please quote the complex ACs here, then I can add the terms when they have been created.

Thanks, Birgit

bmeldal commented 8 years ago

From @NancyCampbell and @rachhuntley (Rachael Huntley): There are currently definitions for these RNAs in the Sequence Ontology, but they are so don't qualify as interactors in IntAct. However, their def could be incorporated into the ChEBI def and an xref added to the terms in the SO.

miRNA: http://www.sequenceontology.org/browser/current_svn/term/SO:0000276 def: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene (or the product of other non coding RNA genes. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (usually via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors. synonyms: micro RNA, microRNA, small temporal RNA, stRNA, SO:0000649 PMID:11081512
PMID:12592000

siRNA: http://www.sequenceontology.org/browser/current_svn/term/SO:0000646 def: A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. SRNAs trigger the cleavage of their target molecules. synonym: small interfering RNA PMID:12592000