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ebi-pf-team / interproscan

Genome-scale protein function classification
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problem with annotation IPR00816 #260

Closed jalan01 closed 2 years ago

jalan01 commented 2 years ago

Hello, There is a discrepancy between the annotation of entry A0A075FKY9 as it appears in the Interpro database and when using the Interproscan function. The sequence regions identified as containing collagen triple-helical repeat (IPR00816) are different (please see attached picture. Inspection of the fasta file suggests the later to be correct. What could be causing this?

Screenshot 2022-04-04 at 21 18 26 Screenshot 2022-04-04 at 21 20 38
matthiasblum commented 2 years ago

Hi @jalan01 ,

Sorry for the late reply.

InterProScan does not report InterPro matches. It reports matches from various analyses/databases (such as Pfam, PANTHER, CDD, etc.). On the InterPro website, when a model/signature (e.g. PF01391) is integrated in an InterPro entry, we add an InterPro annotation/track. This is more useful when the entry integrates more than one signature, as it gives an overall idea of the coverage.

We found a bug in the InterPro website, where the InterPro annotation/track is not correctly built for InterProScan results: ProteinsWebTeam/interpro7-client#386.