The illusion of polygenic disease risk prediction, Wald et al.
The fact that a strong risk factor can be a poor screening test may seem counterintuitive. The paradox is largely explained by the fact that odds ratios or hazard ratios typically compare risks in the tails of a single risk distribution,but these ratios ignore the proportions of individuals who will or will not develop the disease that fall in the region between the tails of the distribution.
Wald NJ, Morris JK. Assessing risk factors as potential screening tests. A simple assessment tool. Arch Intern Med 2010.
Presents an interactive tool for converting risk factors to specificity and sensitivity
Gibson, G. On the utilization of polygenic risk scores for therapeutic targeting
The illusion of polygenic disease risk prediction, Wald et al.
Wald NJ, Morris JK. Assessing risk factors as potential screening tests. A simple assessment tool. Arch Intern Med 2010.
Presents an interactive tool for converting risk factors to specificity and sensitivity
Gibson, G. On the utilization of polygenic risk scores for therapeutic targeting
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008060
Subclinical thyroid dysfunction symptoms in older adults: cross-sectional study in UK primary care
TSH screening finds subclinical thyroid dysfunction but with no symptom burden https://bjgp.org/content/early/2020/01/13/bjgp20X708065