Targeted analysis of lung diseases

emdann / sc_target_evidence

Meta-analysis of drug target evidence in single-cell data

BSD 3-Clause "New" or "Revised" License

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Closed emdann closed 10 months ago

emdann commented 1 year ago

Compare 2 diseases with and without genetic evidence (e.g. COPD and pulmonary fibrosis) - which successful targets are prioritized by single-cell evidence?
Why is there no genetic evidence for some of these diseases? Is it lack of GWAS studies or no significant hits?
Are targets with sc evidence associated with GWAS variants for lung function?

emdann commented 1 year ago

[ ] Repeat download and DE analysis of lung samples (pulmonary fibrosis and COPD first)
[ ] Download targets with lung function genetic association