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eringill / chronic_infection_python

A simple GUI that allows users to check whether mutations from a SARS-CoV-2 genome best fit a mutational distribution of genomes derived from global, chronic, or deer infections.
https://eringill.shinyapps.io/covid-mutation-distributions/
MIT License
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One mutation enough? #6

Closed fionabrinkman closed 3 weeks ago

fionabrinkman commented 3 weeks ago

if I enter in just one mutation, it still gives me a result. I’m not sure about this, but do you want to set some sort of minimum for how many mutations a list, or have a little warning that based on mutation this is not very reliable?

eringill commented 3 weeks ago

This relates to the power analysis that Sally conducted here.

I don't want to get into the weeds with this, as it will be described in the associated preprint. I can add a tool-tip that says "power analyses suggest that a minimum of 10 lineage-defining mutations are needed for accurate results".