what is the principle of copy number calculating between tumor and WT?

etal / cnvkit

Copy number variant detection from targeted DNA sequencing

http://cnvkit.readthedocs.org

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what is the principle of copy number calculating between tumor and WT? #702

Open jlchen5 opened 2 years ago

jlchen5 commented 2 years ago

The .cnr files are already provided the log2(copy ratio). However it does not show the calculating principle between tumor and WT in the published paper on PLOS. Does anyone know the progress of the computation? Thx!!!