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evotools / hapbin

Efficient program for calculating Extended Haplotype Homozygosity (EHH) and Integrated Haplotype Score (iHS)
GNU General Public License v3.0
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iHS Results Interpretation #66

Closed YingLi13 closed 3 years ago

YingLi13 commented 3 years ago

Hi~ I‘ve completed iHS analysis, but I don't really understand the results.

  1. Why some iHS values is negative
  2. Compara to iHS values, Std iHS is more significant for selective signal identified？
prenderj commented 3 years ago

Hi

I would suggest having a read of the original paper that describes the iHS statistic (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1382018/). This will illustrate why have negative values (e.g. see Figure 4) and the difference between the standardised and unstandardised iHS values

On Tue, 9 Nov 2021 at 09:02, YingLi13 @.***> wrote:

Hi~ I‘ve completed iHS analysis, but I don't really understand the results.

  1. Why some iHS values is negative
  2. Compara to iHS values, Std iHS is more significant for selective signal identified？

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