This refines pathway interaction descriptions in the related genes kit. It gives more scientific insight at a glance.
Previously, all interactions would be summarized as "interacts with Foo", where "Foo" was the searched gene. Now, these descriptions are often more specific. Instead of merely knowing gene A "interacts with" gene B, we can know it "stimulates" or "inhibits" or several other more granular types of interactions. In addition to finer types of interactions, their directionality is also indicated, e.g. "inhibits" vs. "is inhibited by".
The refined interaction data is encoded in WikiPathways GPML files, and fetched via the WIkiPathways API. The various types of interactions are described in the Formal Mim Notation Specification.
Below is a comparison showing the old (top) and new (bottom) descriptions
This refines pathway interaction descriptions in the related genes kit. It gives more scientific insight at a glance.
Previously, all interactions would be summarized as "interacts with Foo", where "Foo" was the searched gene. Now, these descriptions are often more specific. Instead of merely knowing gene A "interacts with" gene B, we can know it "stimulates" or "inhibits" or several other more granular types of interactions. In addition to finer types of interactions, their directionality is also indicated, e.g. "inhibits" vs. "is inhibited by".
The refined interaction data is encoded in WikiPathways GPML files, and fetched via the WIkiPathways API. The various types of interactions are described in the Formal Mim Notation Specification.
Below is a comparison showing the old (top) and new (bottom) descriptions
https://user-images.githubusercontent.com/1334561/148144073-256f829b-00ef-43d9-9735-644f7fbf7385.mov