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fauconab / PolygenicRiskScores.jl

Polygenic Risk Scoring in pure Julia
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Status of multi-ancestry support? #13

Open mglev1n opened 1 year ago

mglev1n commented 1 year ago

It looks like there is a branch abf/transancestry that provides the multiancestry PRS functionality included in PRScsx (https://github.com/getian107/PRScsx). In some simple testing this branch appears to function correctly, but was curious about the official status of this branch? Thanks for the great package/optimizations.

jpsamaroo commented 1 year ago

Hi @mglev1n! There are some inaccuracies that we've experienced with that branch in our testing (compared to PRScsx), hence why it hasn't yet been merged.

mglev1n commented 1 year ago

There are some inaccuracies that we've experienced with that branch in our testing (compared to PRScsx)

Did you have a sense of where/why this might be occurring? Happy to take a stab at troubleshooting

jpsamaroo commented 1 year ago

No idea at all (it's probably somewhere in the MCMC code, which is large); we're not entirely familiar with the revised algorithm in PRScsx, so it's hard to figure out where things are going wrong. Any help is appreciated!