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Longevity: Fasting regimens based on biomarker state changes rather than time #23

Open jdhodgkins opened 2 years ago

jdhodgkins commented 2 years ago

Bounties for Foresight Technical Groups

Each of these will run for 6 weeks, the objective is to stimulate conversation and get people thinking about interesting and relevant future science. Submissions will be in the form of project proposals for solving these issues, and several winners will be chosen for each category. A short overview on the problem, a description of a solution, and your plan to implement it are required in the submission.

Fasting regimens based on biomarker state changes rather than time

When people are told to fast, they are given a certain timeframe usually measured in days. But these times are likely different for different people – how might we develop a fasting regimen based on biomarkers instead?

Submit your bounty-response below for your chance to be rewarded 0.15 ETH.

gitcoinbot commented 2 years ago

Issue Status: 1. Open 2. Started 3. Submitted 4. Done

This issue now has a funding of 0.15 ETH (458.7 USD @ $3057.98/ETH) attached to it as part of the https://github.com/foresight-org fund.

gitcoinbot commented 2 years ago

Issue Status: 1. Open 2. Started 3. Submitted 4. Done

Work has been started.

These users each claimed they can complete the work by 5 hours from now. Please review their action plans below:

1) sprinkles1113 has started work.

Discuss how might we develop a fasting regimen based on biomarkers 2) ify01 has started work.

i will give my best project proposal on this issue. 3) zauberkugel2 has started work.

I think you'll need to tell us what the specific aim of the fast is, in order to get meaningful responses. 4) idonai has started work.

Developing a fasting regimen based on biomarkers is quite hard. Not due to a lack of biomarkers, of which there are multiple, but because not every person fasts for the same reasons. Some people fast for weight loss, blood pressure management, improving health, etc. Luckily most of these are quite related and might be accesses individually when looking at a panel of biomarkers.

Some relatively easy to access biomarkers which are known to decrease during water fasting include:

Biomarkers levels that would be more informative but require blood include:

If the goal is autophagy it might be interesting to measure mRNA levels in blood of various autophagy markers including: LC3, p62, Beclin-1, ULK1 5) sepandhaghighi has started work.

Developing a Smart Regimen Based on Biomarkers

Learn more on the Gitcoin Issue Details page.

gitcoinbot commented 2 years ago

Issue Status: 1. Open 2. Started 3. Submitted 4. Done

Work for 0.15 ETH (288.73 USD @ $1924.84/ETH) has been submitted by:

  1. @sepandhaghighi

@jdhodgkins please take a look at the submitted work:

gitcoinbot commented 2 years ago

Issue Status: 1. Open 2. Started 3. Submitted 4. Done

The funding of 0.15 ETH (271.25 USD @ $1808.33/ETH) attached to this issue has been approved & issued to @sepandhaghighi.